Frequently Asked Questions
A stress test is used by doctors to diagnose heart disease. If your doctor wants you to have a stress test, you may have symptoms of heart disease or certain risk factors for it. Not everyone who has a stress test has heart disease. Your test results can help your doctor determine if you have heart disease or if you may be at risk for a heart attack.
Coronary artery disease (CAD) is a type of heart disease. CAD occurs when the arteries that carry blood to the heart become clogged with fatty deposits (plaque).1,2 These buildups can clog the vessels, reducing the amount of blood that flows to your heart.1 When that happens, more serious problems can develop including:
- Chest pain, or angina
- Heart attack
- Heart failure
- Changes in your heart rhythm
Although there is no cure for CAD, there are many treatments available to help you. And there are steps you can take to lower your risk and help improve the health of your heart and your blood vessels.
Common risk factors that doctors look for are:4,5,6,7
- Age and gender
- Family history of heart disease
- High levels of LDL (“bad”) cholesterol
- Low levels of HDL (“good”) cholesterol
- High blood pressure
- Lack of exercise
- Being overweight
- Poor diet
- Drinking too much alcohol
The more of these risk factors you have, the greater are your chances of developing heart disease.5 A stress test with Cardiolite® can help your doctor determine if this is a problem you may face.
Cardiolite® (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection) is an imaging agent used in stress tests to see how well blood is flowing to and through your heart.7 If you have a stress test with Cardiolite® your doctor will inject you with a small amount of radioactive Cardiolite®1 and use a special camera to take pictures of your heart. Please discuss any concerns regarding this procedure with your doctor.
Your doctor suspects you may have heart disease and wants to confirm it.
Your doctor may suspect coronary artery disease if you have chest pressure or other symptoms.1 Having certain risk factors such as high blood pressure or family history of heart disease could also increase your chance of having coronary artery disease. It’s important to be tested, because some people with heart disease feel no symptoms at all.
Your doctor already knows you have heart disease and wants to monitor your condition.
If you have already been diagnosed with heart disease, your doctor may ask for a stress test to:
- Look for any heart damage you may have
- Track the progress of your condition and assess your risk for problems in the future
- Determine how well your treatment is working
Indications and Usage for Cardiolite®:
Myocardial Imaging: CARDIOLITE® (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection), is a myocardial perfusion agent that is indicated for detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects), in evaluating myocardial function and developing information for use in patient management decisions. CARDIOLITE® evaluation of myocardial ischemia can be accomplished with rest and cardiovascular stress techniques (e.g. exercise or pharmacologic stress in accordance with the pharmacologic stress agent’s labeling).
IMPORTANT SAFETY INFORMATION:
CARDIOLITE® has been rarely associated with acute severe allergic and anaphylactic events of angioedema and generalized urticaria. In some patients the allergic symptoms developed on the second injection during CARDIOLITE® imaging. The most frequently reported adverse events include headache, chest pain/angina, ST segment changes on ECG, nausea, and abnormal taste and smell.
Infrequently, death has occurred 4 to 24 hours after Tc99m Sestamibi use and is usually associated with exercise stress testing (See Section 5.2). Pharmacologic induction of cardiovascular stress may be associated with serious adverse events such as myocardial infarction, arrhythmia, hypotension, bronchoconstriction and cerebrovascular events.
WARNINGS AND PRECAUTIONS:
In studying patients in whom cardiac disease is known or suspected, care should
be taken to assure continuous monitoring and treatment in accordance with safe,
accepted clinical procedure.
Caution should be exercised and emergency equipment should be available when administering CARDIOLITE®.
Before administering CARDIOLITE® patients should be asked about the possibility of allergic reactions to either CARDIOLITE® or MIRALUMA®.
MIRALUMA® is an identical compound used in breast imaging.
The contents of the vial are intended only for use in the preparation of Technetium Tc99m Sestamibi and are not to be administered directly to the patient without first undergoing the preparative procedure.
Please see full Prescribing Information: Cardiolite® (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection)
Indications and Usage for Thallous Chloride Tl 201 Injection:
Thallous Chloride TI 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction. It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect.
Thallous Chloride TI 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease).
It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia.
Thallous Chloride TI 201 is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination. Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.
Important Safety Information:
Following the administration of Thallous Chloride Tl 201 Injection, adverse anaphylactoid reactions have been reported (characterized by cardiovascular, respiratory, and cutaneous symptoms), some severe enough to require treatment. Hypotension, pruritus, flushing and diffuse rash which responds to antihistamines have been reported. Other reported events include itching, nausea/vomiting, mild diarrhea, tremor, shortness of breath, chills, fever, conjunctivitis, sweating and blurred vision.
In studying patients in whom myocardial infarction or ischemia is known or suspected, care should be taken to assure continuous clinical monitoring and treatment in accordance with safe, accepted procedure. Exercise stress testing should be performed only under the supervision of a qualified physician and in a laboratory equipped with appropriate resuscitation equipment.
The vial stopper contains dry natural rubber latex and may cause allergic reactions in providers or patients who are sensitive to latex.
Data are not available concerning the effect of marked alterations in blood glucose, insulin, or pH (such as is found in diabetes mellitus) on the quality of Thallous Chloride TI 201 Injection scans. Attention is directed to the fact that thallium is a potassium analog, and since the transport of potassium is affected by these factors, the possibility exists that the thallium may likewise be affected.
The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
Thallous Chloride TI 201 Injection, as all radioactive materials, must be handled with care and used with appropriate safety measures to minimize external radiation exposure to patients and to clinical personnel.
Radiopharmaceuticals should be used only by physicians who are qualified by training and experience in the safe use and handling of radionuclides.
Please see full Prescribing Information: Thallous Chloride Tl 201 Injection